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Phentermine is the generic form of the brand-name drugs Adipex-P, Suprenza, and Ionamin, which are used for weight loss. Phentermine decreases appetite and stimulates the body to burn calories more quickly. Fastin, a former brand name for phentermine, is no longer available in the United States. Phentermine is a controlled substance, and should only be taken for a short period of time (no more than three weeks). People taking phentermine should also cut back on calories and try to exercise while taking the drug.
Phentermine is generally prescribed for people who are very overweight with a body-mass index (BMI) greater than 30.
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Phentermine makes the nervous system operate in a kind of “fight-or-flight” mode by stimulating brain chemicals known as neurotransmitters. It was first approved as a diet drug in 1959, and has been on the market in various forms since then.
In the late 1990s, the Food and Drug Administration (FDA) removed a combination diet drug known as fen-phen (for fenfluramine and phentermine) from the market because of evidence that it could damage heart valves. Since then, the FDA has approved phentermine combined with different drugs.